Protein Unfolding Behavior Studied by Elastic Network Model
نویسندگان
چکیده
منابع مشابه
SH3 Domain Unfolding Pathway Studied by Protein Contact Network Model
The approach of complex networks has provided one powerful tool to understand how proteins consistently fold into their native-state structures and the relevance of structure to their function. In this study, a coarse-grained complex network model called Protein Contact Network (PCN) is employed to study the unfolding process of SH3 domain, and the change of the network parameters associated wi...
متن کاملElastic bond network model for protein unfolding mechanics.
Recent advances in single molecule mechanics have made it possible to investigate the mechanical anisotropy of protein stability in great detail. A quantitative prediction of protein unfolding forces at experimental time scales has so far been difficult. Here, we present an elastically bonded network model to describe the mechanical unfolding forces of green fluorescent protein in eight differe...
متن کاملThe Intrinsic Dynamics and Unfolding Process of an Antibody Fab Fragment Revealed by Elastic Network Model
Antibodies have been increasingly used as pharmaceuticals in clinical treatment. Thermal stability and unfolding process are important properties that must be considered in antibody design. In this paper, the structure-encoded dynamical properties and the unfolding process of the Fab fragment of the phosphocholine-binding antibody McPC603 are investigated by use of the normal mode analysis of G...
متن کاملProtein Folding, Unfolding and Aggregation Studied Using an All-Atom Model with a Simplified Interaction Potential
Finding a suitable transferable energy function for modeling of how different proteins fold into their respective native states is a major challenge in biophysics. Here, we discuss an all-atom protein model with implicit water and some studies based on this model. The model has a simplified and computationally convenient energy function. Despite its simplicity, the model has been found to quite...
متن کاملProtein unfolding by mitochondria
Protein unfolding is a key step in the import of some proteins into mitochondria and chloroplasts and in the degradation of regulatory proteins by ATP-dependent proteases. In contrast to protein folding, the reverse process has remained largely uninvestigated until now. This review discusses recent discoveries on the mechanism of protein unfolding during translocation into mitochondria. The mit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.121665